Timisoara Medical Journal

Mupirocin is a topical antibiotic widely used to treat various skin infections caused by Gram-positive and Gram-negative bacteria, being the first-line treatment in the case of an infection with methicillin-resistant Staphylococcus aureus (MRSA). Due to the unique mechanism of action, it does not possess any cross-resistance with other antibiotics, leading to its global use in different hospital departments. The main disadvantage of mupirocin is represented by its pharmacokinetic properties, leading to the main purpose of this study, namely, to fully characterize the physicochemical properties of the active pharmaceutical ingredient. Currently, it is used in different combinations with other active substances, for example metronidazole, to decrease the risk of developing resistance to mupirocin and to improve the therapeutic response. This leads to the second purpose of this study, i.e., to characterize the physico-chemical profile of metronidazole and to find out if there are any chemical interactions between the two compounds, and to establish if there is a possibility of using them in the same pharmaceutical formulation, thus increasing the compliance of the patient to the treatment. Full article

Purpose: To study the characteristics of the third molar by panoramic radiography in a sample of Syrian patients. Materials and methods: We analyzed 335 panoramic radiographs of Syrian patients with at least one third molar. The sample consisted of 169 males (50.5%) and 166 females (49.5%). Third molars were classified according to Pell and Gregory’s classification and Winter’s classification. Results: The incidence of impaction was higher among females than males. The most common pattern was of vertically mandibular third molars at level A and class II, followed by vertically maxillary third molars at level B. Conclusions: The early diagnosis of impacted third molars by panoramic radiographs is useful for determining the position and depth of these molars and for proper planning for extraction. Full article

(1) Background: The aim of this study was to assess the short-term effects of one manual therapeutic intervention by quantifying the biomechanical and viscoelastic properties of upper trapezius myofascial trigger points. (2) Materials and Methods: Fourteen volunteer subjects (six males and eight females) aged 22 to 47 years, with myofascial trigger points in the upper trapezius muscle on both sides participated in this study. The biomechanical and viscoelastic properties were assessed with the Myoton Pro (Estonia) before the application of manual therapy (T0), then immediately after the end of the treatment session (T1) and finally one hour after the end of the treatment session (T2) in order to evaluate the effectiveness of the applied treatment. (3) Results: The oscillation frequency in the right upper trapezius muscle was significantly lower than in the left upper trapezius muscle both immediately, after the end of the manual therapy session (p = 0.03) and one hour after the session (p = 0.03). Regarding the state of tension in the right upper trapezius, a significant decrease was observed one hour after treatment compared to baseline (p = 0.04). In the left upper trapezius muscle, one hour after treatment, the dynamic stiffness value was significantly higher than in the right upper trapezius (p = 0.01). (4) Conclusions: Myotonometry could become a useful method to assess the biomechanical and viscoelastic properties of muscles, identifying trigger points and monitoring the results of therapy. Full article