Timisoara Medical Journal

(1) Background: This research is part of the Romanian oral health survey for children, aiming to determine correlations between the oral health status of 11–14-year-old schoolchildren and their parents’ educational levels, taking into account preventive behaviour and socioeconomic parameters. (2) Methods: a representative sample of 133 schoolchildren (72 boys and 61 girls), average age 12.26 ± 0.6 years, was examined by calibrated dentists. After obtaining ethical approval, a visual examination using ICDAS criteria was performed to classify visual caries lesion severity. Statistical analyses of the data were performed using SPSS 23, Spearman’s rank correlation and the Pearson correlation. (3) Results: Mean DMFT within the sample was 2.93 ± 2.70. High school was the most common level of education completed by the parents. A positive relationship was recorded between the mother’s level of education and the frequency of toothbrushing in children (rs = 0.02 *, p < 0.01), as well as with oral hygiene aids (rs = 0.17 *, p < 0.05). A negative significant correlation resulted between D3T index and the mother’s level of education (rs = −0.26 **, p < 0.01), as well as with the father’s education (rs = −0.17 **, p < 0.01). (4) Conclusions: The results of this study show that high caries prevalence could be associated with low educational level and socio-economic county-level variables, having an impact on the presence and severity of such lesions, as well as the absence of existing treatments. Full article

Background: The aim of this study was to assess the accuracy of printed interim fixed partial dentures (i-DPSs) fabricated on 3D-printed models using different printing angles. Materials and Methods: Six printing angles were chosen, namely 90°, 75°, 60°, 45°, 30° and 15°, to fabricate sixty i-DPSs, ten for each. The measurements were performed at 100 points cervical and 100 points axial occlusal. Statistical analyses were carried out using Med Calc software and the Kolmogorov–Smirnov and Kruskal–Wallis tests. Results: The marginal fit ranged between 39.302 µm and 74.470 µm, with the best values for the 60° (39.302 µm) and 30° (43.287 µm) printing angles. The mean values for the internal fit were between 72.876 µm and 114.26 µm, with the best values for the 30° (72.876 µm) and 60° (78.049 µm) printing angles. The Kruskal–Wallis test returned a p value of p < 0.0001. Full article

Oncological pathology and the management of patient with cancer are real challenges in cardiology practice. Unpredictable situations triggered by this pathology, as well as adverse reactions of oncological therapy on the cardiovascular system, are increasing. A 71-year-old female patient who was known with HER2-positive breast cancer, with sectorial mastectomy and treated with chemo-radio-immunotherapy in 2018, then diagnosed with liver metastases and ulcerated gastric adenocarcinoma in May 2022, was referred to the Cardiology Clinic for chest pain and dyspnea. On the ECG, ST-segment depression was seen in the infero-lateral territory. Positive myocardial necrosis enzymes were documented, and also moderate microcytic hypochromic anemia. The current clinical, electrical, and biological picture was suggestive for acute coronary syndrome. It should be mentioned that the patient has been on monoclonal antibody therapy with Trastuzumab, recently discontinued after echocardiographic evaluation where decreased systolic performance was noted. Considering all the particular aspects of this case, as cardiotoxicity of oncological therapy, acute coronary event and anemic syndrome, multidisciplinary management is required, with adjustment of cardiovascular therapy and cancer treatment. Full article

Post-vaccine adverse reactions are unwanted medical events that concern both the public and healthcare professionals. The objective of this paper is to present a detailed analysis of the case of an extensive local adverse reaction after the administration of a vaccine dose containing diphtheria–tetanus anatoxins. A good knowledge of post-vaccine side effects allows for complete and correct diagnosis, as well as appropriate individualized recommendations. Such an approach contributes to restoring public confidence in vaccines and vaccinations. The patient was a 6-year-old boy, with a history of asthma under chronic treatment with corticosteroids. He developed extensive local inflammatory lesions accompanied by functional disorders of the left arm, which began six hours after the administration of the fifth dose of the diphtheria–tetanus–pertussis–poliomyelitis vaccine. The lesions, which extended to the forearm, were locally treated with antiseptics and systemically treated with hydrocortisone hemisuccinate. They completely remitted within 14 days. Laboratory investigations revealed neutrophilia (6,870 neutrophils/µL), which could be related to the long-term treatment with steroids. The investigation needed the plasma concentration of diphtheria and tetanus anatoxins antibodies and the pro-inflammatory cytokines to be complete. Full article

Aortic stenosis is the most common valvular disease worldwide. Coronary artery disease (CAD) is often associated with degenerative aortic stenosis, particularly among older patients. Surgical treatment of the combined pathologies is highly recommended because the results are durable. Assessment of mitochondrial respiration in blood cells has recently emerged as a potential biomarker of the bioenergetic health but data regarding the changes in the setting of cardiopulmonary bypass (CPB) are scarce. A 67-year-old man was referred to the clinic for progressive breathlessness, constrictive thoracic pain and fatigue. Investigations revealed severe aortic stenosis and triple-vessel CAD. The aortic valve was replaced with a mechanical aortic prosthesis and coronary artery bypass graft was performed under mild hypothermia. We assessed platelet complex I (CI)- and complex II (CII)-dependent mitochondrial respiration and found a significant increase in the net active respiration supported by CI and the maximal uncoupled respiration in platelets harvested after CPB compared to those isolated pre-CPB. At variance, the active coupled respiration and electron transfer capacity for CII were decreased. The relative contribution of the complex cardiac pathology and CPB to the impairment of CII-dependent respiration and/or a possible relation with patients’ outcome are worth further investigation in a pilot study. Full article