Parathyroid Elastography―Elastography Evaluation Algorithm
1 Department of Doctoral Studies, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania;
2 Department of Endocrinology, Victor Babeș University of Medicine and Pharmacy, 300736 Timișoara, Romania;
3 2nd Department of Internal Medicine, Victor Babeș University of Medicine and Pharmacy, 300736 Timișoara, Romania; (I.S.); (A.S.)
4 B Braun Avitum Dialysis Medical Center, 307350 Remetea Mare, Romania;
5 Department of Mathematics and Biostatistics, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania;
* Correspondence: (D.A.); (A.B.); Tel.: +40-744690639 (D.A.); +40-743451118 (A.B.)
* Author to whom correspondence should be addressed.
Received: 12 Aug 2020 / Revised: 10 Oct 2020 / Accepted: 12 Oct 2020 / Published: 3 Dec 2020
Abstract
(1) Background: Primary hyperparathyroidism is a common disorder of the parathyroid glands and the third most frequent endocrinopathy, especially among elderly women. Secondary hyperparathyroidism is a common complication of chronic kidney disease, associated with high cardiovascular morbidity and mortality. In both primary and secondary hyperparathyroidism, the need to correctly identify the parathyroid glands is mandatory for a better outcome. Elastography can be an effective tool in the diagnosis of parathyroid lesions, by differentiating possible parathyroid lesions from thyroid disease, cervical lymph nodes, and other anatomical structures. There are currently no guidelines or recommendations and no established values on the elasticity of parathyroid lesions. (2) Material and Methods: In our studies, we have evaluated, by Shear Wave elastography (SWE), both primary and secondary hyperparathyroidism, determining that parathyroid glands have a higher elasticity index than both thyroid tissue and muscle tissue. (3) Results: For primary hyperparathyroidism, we have determined, using 2D-SWE, the parathyroid adenoma tissue (mean elasticity index (EI) measured by SWE 4.74 ± 2.74 kPa) with the thyroid tissue (11.718 ± 4.206 kPa) and with the surrounding muscle tissue (16.362 ± 3.829 kPa). For secondary hyperparathyroidism, by SWE elastographic evaluation, we have found that the mean EI in the parathyroid gland was 7.83 kPa, a median value in the thyroid parenchyma of 13.76 kPa, and a mean muscle EI value at 15.78 kPa. (4) Conclusions: Elastography can be a useful tool in localizing parathyroid disease, whether primary or secondary, by correctly identifying the parathyroid tissue. We have determined that an EI below 7 kPa in SWE elastography correctly identifies parathyroid tissue in primary hyperparathyroidism, and that a cut-off value of 9.98 kPa can be used in 2D-SWE to accurately diagnose parathyroid disease in secondary hyperparathyroidism.
Keywords: elastography; parathyroid; hyperparathyroidism; shear wave elastography; ultrasonography; parathyroid adenoma; ultrasonography; elastography; strain elastography
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CITE
Cotoi, L.; Amzăr, D.; Sporea, I.; Borlea, A.; Schiller, O.; Schiller, A.; Pop, G.N.; Stoian, D. Parathyroid Elastography―Elastography Evaluation Algorithm. Timisoara_Med 2020, 2020, 5.
Cotoi L, Amzăr D, Sporea I, Borlea A, Schiller O, Schiller A, Pop GN, Stoian D. Parathyroid Elastography―Elastography Evaluation Algorithm. Timisoara Medical Journal. 2020; 2020(1):5.
Cotoi, Laura; Amzăr, Daniela; Sporea, Ioan; Borlea, Andreea; Schiller, Oana; Schiller, Adalbert; Pop, Gheorghe Nicușor; Stoian, Dana. 2020. "Parathyroid Elastography―Elastography Evaluation Algorithm." Timisoara_Med 2020, no. 1: 5.
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